Ipriflavone
Synopsis of ipriflavone
Ipriflavone is a synthetic isoflavone derivative chemically related to naturally occurring flavonoids found in soy and other plants. It is primarily used as a bone-support supplement, particularly in postmenopausal women and individuals at risk for osteoporosis. Unlike phytoestrogens that mimic estrogen’s effects, ipriflavone exerts its influence by modulating bone metabolism without directly stimulating estrogen receptors, making it a non-hormonal alternative for bone health.
Ipriflavone works by inhibiting osteoclast activity (cells that break down bone) while promoting osteoblast activity (cells that build bone), thus helping to preserve or increase bone mineral density (BMD). It also improves calcium absorption in the intestines and helps reduce bone resorption, especially during periods of rapid bone turnover, such as after menopause.
Studies have shown that ipriflavone can:
- Help maintain bone mass in postmenopausal women
- Reduce the risk of vertebral fractures
- Complement calcium and vitamin D in osteoporosis prevention
- Support bone healing in some orthopedic settings
It is typically taken in doses of 600 mg per day, often in tablet or capsule form, and is best used under supervision in long-term bone health programs.
Historical Use
Ipriflavone does not have roots in traditional medicine as it is a laboratory-synthesized compound, first developed in the 1970s in Japan during research into non-hormonal treatments for osteoporosis. It became widely used in Europe and Asia in the following decades as a bone-preserving agent for aging populations, particularly postmenopausal women who could not tolerate hormone replacement therapy (HRT).
Though not used in herbal or folk medicine, its development was inspired by the protective effects of natural isoflavones in soy, which were noted to correlate with lower rates of osteoporosis in Asian populations. This connection led to the design of ipriflavone as a more targeted and stable molecule with stronger and more predictable bone-supportive actions.
Today, ipriflavone remains a component of integrative bone health protocols, particularly for individuals seeking non-hormonal approaches to osteoporosis prevention and treatment. While its use has declined in some regions due to mixed clinical trial results, it continues to be valued as a specialized nutraceutical option when used alongside calcium, vitamin D, magnesium, and lifestyle strategies to maintain skeletal integrity.
Ipriflavone is used for these health conditions
Osteoporosis (Scientific)
ipriflavone is used to support these body systems
Skeletal System (Bones) (Scientific)
