Hydroxycitric acid
Synopsis of hydroxycitric acid
Hydroxycitric acid (HCA) is a naturally occurring compound primarily extracted from the rind of Garcinia cambogia, a tropical fruit native to India and Southeast Asia. It is classified as a citric acid derivative and is widely known for its role in weight management supplements, where it is promoted for its ability to reduce appetite, inhibit fat production, and support metabolic health.
HCA works by inhibiting ATP-citrate lyase, an enzyme involved in the conversion of excess carbohydrates into fat. By blocking this enzyme, HCA may help reduce lipogenesis (fat formation) and encourage the body to use existing fat stores for energy. It is also thought to increase serotonin levels in the brain, which may contribute to appetite suppression, mood improvement, and reduced emotional eating.
In addition to its metabolic effects, HCA exhibits mild antioxidant properties and may support blood sugar balance, lipid profiles, and overall metabolic function when combined with proper diet and exercise.
HCA is most commonly found in capsules, tablets, or powdered extracts standardized to 50–60% HCA, either as Garcinia cambogia extract or a standalone compound.
Historical Use
Although HCA was isolated and studied in the mid-20th century, its source—Garcinia cambogia—has been used for centuries in traditional Ayurvedic and Southeast Asian medicine. The dried rind of the fruit, known as “kudam puli” or “malabar tamarind”, was traditionally used to aid digestion, reduce intestinal gas, treat parasites, and enhance flavor in cooking. It was also used in cleansing and detoxifying formulations, particularly for digestive sluggishness or bloating.
The modern application of HCA as a weight loss supplement became popular in the 1990s, following research that highlighted its potential role in reducing fat accumulation and appetite. While results in clinical trials have been mixed—largely depending on dosage, duration, and dietary context—HCA continues to be marketed as a natural metabolic aid, often blended with chromium, green tea extract, or carnitine for synergistic effects.
Today, hydroxycitric acid remains a popular ingredient in natural weight management and metabolic health protocols, reflecting a fusion of traditional use and modern nutritional science aimed at supporting fat metabolism, satiety, and energy balance.
Hydroxycitric acid is used for these health conditions
Appetite (excessive) (Scientific)
Body Building (Scientific)
Fat Cravings (Scientific)
Fat Metabolism (poor) (Scientific)
Metabolic Syndrome (Scientific)
Sugar Cravings (Scientific)
Weight Loss (Scientific)
