Citrulline malate
Other names for Citrulline malate
citruilline malate
citruline malate
citrulin maleate
citrulline dl malate
citrulline dl-malate
citrulline dl-malate 2:1
citrulline ethyl ester malate
citrulline malate
citrulline-malate
citrulline malate 1:1
dicitrulline malate
full yield citrulline
hydronox
l-citruline dl-malate
l- citrulline dl malate
l- citrulline dl- malate
l-citrulline dl malate
l-citrulline dl-malate
l-citrulline-dl-malate
l-citrulline dl-malate 1:1
l-citrulline dl malate 2:1
l-citrulline dl-malate 2:1 powder:
l-citrulline l-malate
l-citrulline malate
l-citrulline-malate
l-citrulline malate and pepform l-citrulline peptides
l-citrulline malate extract
l-citrulline-malic acid infusion
tri-citrulline malate
vasi pump complex
Synopsis of Citrulline malate
History
Citrulline malate, a compound formed from the non-essential amino acid L-citrulline and malic acid, has gained prominence in modern nutritional supplements, particularly for its role in enhancing athletic performance and promoting vascular health. Historically, the origins of citrulline trace back to the early 20th century when it was first isolated from watermelon (Citrullus vulgaris), a fruit long appreciated in traditional medicine for its hydrating and restorative properties. In various folk remedies, watermelon and related cucurbits were valued for their ability to cool the body, support kidney function, and promote detoxification—benefits now partially attributed to their citrulline content.
While citrulline itself was not explicitly identified and used in ancient herbal medicine, its natural sources were integral components in herbal combinations designed to rejuvenate the body and support overall wellness. For example, traditional practitioners often combined watermelon with other diuretic and anti-inflammatory herbs to enhance urinary health and reduce fatigue. Such combinations were believed to purify the blood and support cardiac health, echoing citrulline's modern reputation for improving circulation and reducing muscle soreness.
In contemporary formulations, citrulline malate is often blended with other amino acids, herbal extracts, and nutrients to optimize energy production and recovery. Its unique ability to boost nitric oxide levels and buffer lactic acid makes it an invaluable contributor to physical performance, stamina, and post-exercise recovery. Overall, citrulline malate stands as a testament to the enduring value of nature-derived remedies, seamlessly bridging traditional wisdom and modern scientific understanding to promote health and vitality.
Traditional and scientific validation
Citrulline malate is a compound often featured in sports nutrition supplements, particularly pre-workout formulas, due to its reputed ability to enhance exercise performance and reduce fatigue. Historically, citrulline was first identified in watermelon (Citrullus vulgaris), and its malate combination was developed to potentially improve bioavailability and synergistic effects in energy production cycles.
Scientifically, citrulline malate has been the subject of several clinical investigations. Studies have shown that citrulline plays a key role in the urea cycle, helping to detoxify ammonia and support nitric oxide (NO) production, which can improve blood flow and nutrient delivery to muscles. A frequently cited clinical study published in the Journal of Strength and Conditioning Research (2010) found that athletes supplementing with citrulline malate experienced reduced muscle fatigue and improved exercise performance during high-intensity resistance workouts. Additional research has indicated possible benefits in reducing soreness and supporting recovery post-exercise.
While these findings are promising, the overall body of evidence is still emerging. Some studies report moderate positive effects, while others show minimal changes compared to placebo. As a result, experts note that more large-scale, long-term studies are needed to confirm and clarify citrulline malate’s full impact on performance, endurance, and recovery.
Nevertheless, citrulline malate remains a popular ingredient in nutritional products due to its potential to support athletic performance and recovery. Its safety profile is generally favorable, and its physiological roles provide a solid scientific rationale for continued exploration in sports and exercise nutrition.
Citrulline malate is used for these health conditions
Athletic and Exercise Aids (Scientific)
Circulation (poor) (Scientific)
Energy (lack of) (Scientific)
Fatigue (Scientific)
Muscle Tone (lack of) (Scientific)
Citrulline malate is used to support these body systems
Arteries (Scientific)
Blood (Scientific)
Circulatory System (Scientific)
Muscles (Scientific)
