Centella triterpenes
Synopsis of Centella triterpenes
History
Centella triterpenes, bioactive compounds derived from the plant Centella asiatica (commonly known as Gotu Kola), have played a significant role in traditional medicine across Asia for centuries. Historically, Gotu Kola has been esteemed in Ayurvedic, Traditional Chinese, and Indonesian folk medicine for its remarkable healing properties. Its triterpenes—primarily asiaticoside, madecassoside, and asiatic acid—are credited with a range of therapeutic effects.
Centella triterpenes were traditionally used to support wound healing, with ancient healers applying crushed leaves directly to cuts, burns, and skin irritations to accelerate recovery and reduce scarring. It was also a popular remedy for managing leprosy, varicose veins, and disorders of the skin, owing to its anti-inflammatory and collagen-promoting actions. In Ayurveda, Centella is considered a "medhya rasayana," a rejuvenator for the mind, believed to enhance memory, concentration, and longevity. In Traditional Chinese Medicine, it is associated with calming the spirit and promoting clarity.
Beyond its solo use, Centella triterpenes are frequently combined with other botanicals for synergistic effects. Herbal combinations with ginseng, ashwagandha, or bacopa are common in cognitive and adaptogenic formulas, while blends with calendula or aloe are favored for skin health. These combinations are believed to amplify healing, soothe inflammation, and foster holistic well-being.
Modern research continues to validate these traditional uses, highlighting Centella triterpenes' contributions to skin care, vascular health, and cognitive support. Their enduring presence in both ancient remedies and contemporary nutritional products affirms their invaluable role in promoting wellness naturally.
Traditional and scientific validation
Centella triterpenes, derived from the herb Centella asiatica (commonly known as gotu kola), have a long history of use in traditional medicine systems such as Ayurveda and Traditional Chinese Medicine. Historically, Centella has been utilized to promote wound healing, support cognitive function, and enhance skin health. The key bioactive compounds, known as triterpenes (including asiaticoside, madecassoside, and asiatic acid), are believed to underpin many of the plant’s beneficial properties.
In recent years, scientific interest in Centella triterpenes has grown, with several clinical and preclinical studies exploring their effects. Research indicates that these compounds may support collagen synthesis and aid in the healing of minor wounds and ulcers. Some clinical studies have suggested improvements in venous insufficiency and microcirculatory function, potentially benefiting individuals with varicose veins or related conditions. Additionally, preliminary research points to neuroprotective and anxiolytic (anxiety-reducing) effects, although larger, well-controlled trials are still needed to confirm these findings.
Centella triterpenes are also being investigated for their antioxidant and anti-inflammatory activities, which could have broader implications for overall health and wellness. While the traditional uses of Centella asiatica are well-documented, and early scientific evidence is promising, more rigorous, large-scale human studies are necessary to fully validate its efficacy for specific health conditions. Nonetheless, Centella triterpenes continue to contribute positively to nutritional and wellness products, appreciated for their safety profile and multifaceted potential benefits.
Centella triterpenes is used for these health conditions
Abrasions (Scientific)
Anxiety (Traditional)
Arthritis (Scientific)
Bruises (healing) (Scientific)
Burns and Scalds (Scientific)
Circulation (poor) (Scientific)
Cuts (Scientific)
Dermatitis (Scientific)
Diabetes (Scientific)
Digestion (poor) (Traditional)
Eczema (Scientific)
Edema (Scientific)
Fatigue (Traditional)
Gastritis (Traditional)
Inflammation (Scientific)
Injuries (Scientific)
Insomnia (Traditional)
Memory and Brain Function (Scientific)
Pain (general remedies for) (Traditional)
Psoriasis (Scientific)
Scars / Scar Tissue (Scientific)
Stress (Traditional)
Ulcers (Scientific)
Varicose Veins (Scientific)
Wounds and Sores (Scientific)
Wrinkles (Scientific)
Centella triterpenes is used to support these body systems
Blood (Traditional)
Brain (Traditional)
Capillaries (Scientific)
Circulatory System (Scientific)
Digestive System (Traditional)
Gastrointestinal Tract (Scientific)
Immune System (Traditional)
Joints (Traditional)
Nerves (Traditional)
Skin (Scientific)
Small Intestines (Traditional)
Veins (Scientific)
