Cardarine

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Other names for Cardarine

2-(2-methyl-4(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)-acetic acid
{4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid
cardar1ne
cardarine
endurobol
gw-501516

Synopsis of Cardarine

History

Cardarine, also known as GW501516, is a synthetic compound often grouped with performance-enhancing substances, though it is not an herb and does not have a deep-rooted history in traditional medicinal practices. Developed in the 1990s by pharmaceutical companies, Cardarine was originally investigated for its potential to treat metabolic and cardiovascular diseases, such as obesity, diabetes, and dyslipidemia. Its unique mechanism as a PPARδ receptor agonist allows it to enhance the body’s ability to burn fat, improve endurance, and modulate lipid metabolism.

Though not traditionally used as a remedy in ancient or herbal medicine, Cardarine has been incorporated into modern nutritional products aimed at supporting athletic performance and weight management. Its innovative profile has made it a popular component in various supplement stacks and combinations, particularly among athletes and fitness enthusiasts seeking to maximize fat loss while preserving muscle mass and increasing stamina. In these combinations, Cardarine is often paired with natural herbal ingredients such as green tea extract, caffeine, and L-carnitine, creating synergistic effects that further support metabolism, energy, and endurance.

The contributions of Cardarine to the field of nutritional science are notable. It has provided a new approach to managing metabolic health and enhancing athletic performance, inspiring further research and development into targeted metabolic modulators. While continued research and responsible use are essential, Cardarine's impact on modern sports nutrition and its potential for metabolic support stand as testament to its positive contributions in these domains.

Traditional and scientific validation

Cardarine, also known as GW501516, is a compound initially developed in the 1990s as a potential treatment for metabolic and cardiovascular diseases. It is classified as a selective androgen receptor modulator (SARM) and functions primarily as a PPARδ (Peroxisome Proliferator-Activated Receptor delta) agonist. Cardarine garnered interest due to its ability to influence metabolic pathways, particularly those involved in fat burning and energy utilization.

Preclinical studies in animal models demonstrated that Cardarine could enhance endurance, improve lipid metabolism, and reduce obesity-related markers. For instance, research published in Cell Metabolism (2008) showed that mice treated with GW501516 experienced increased running endurance and a shift toward fat utilization as an energy source. These findings contributed to its popularity in the fitness and bodybuilding communities, where Cardarine is often used for its purported ability to support fat loss and athletic performance.

Despite promising animal data, human clinical trials on Cardarine remain limited. Early-phase studies indicated potential benefits for lipid profiles, such as raising HDL cholesterol and lowering triglycerides. However, concerns emerged regarding its safety, as longer-term animal studies indicated an increased risk of cancer at high doses. Consequently, Cardarine was not advanced for pharmaceutical approval and is banned by the World Anti-Doping Agency (WADA).

While anecdotal evidence and preclinical research highlight Cardarine’s potential contributions to metabolism and endurance, robust clinical validation in humans is still lacking. More research is needed to fully understand its efficacy and safety profile. Nevertheless, Cardarine continues to be investigated for its novel mechanisms and possible applications in metabolic health.

Cardarine is used for these health conditions

Athletic and Exercise Aids (Scientific)
Body Building (Scientific)
Cholesterol (high) (Scientific)
Fat Metabolism (poor) (Scientific)
Metabolic Syndrome (Scientific)
Triglycerides (high) (Scientific)
Weight Loss (Scientific)

Cardarine is used to support these body systems

Mitochondria (Scientific)
Muscles (Scientific)

Products containing Cardarine

We currently have no products on Caring Sunshine that contain this ingredient.