Alpha-GPC
Other names for Alpha-GPC
a-gpc
alcolec gpc
alpha glycerl-phosphoryl choline
alpha-glycerolphosphocholine
alpha glycerol phosphoryl choline
alpha-glycerolphosphorylcholine
alpha-glycerolphosphorylcholine powder
alpha-glycerophosphatidylcholine
alpha glycerophosphocholine
alpha-glycerophosphocholine
alpha-glyceryl phosphatidylcholine
alpha-glyceryl phosphatidylcholine powder
alpha-glyceryl phosphory
{alpha}-glycerylphosphorycholine
alpha glycerylphosphorycholine
alpha glyceryl phosphoryl choline
alpha glyceryl phosphorylcholine
alpha glycerylphosphorylcholine
alpha-glyceryl phosphoryl choline
alpha-glycerylphosphorylcholine
alpha-glyceryl phosphoryl choline complex
alpha-glycerylphosphorylcholine, powder
alpha gpc
alpha-gpc
alpha-gpc complex
alpha-gpc (l-alpha-glycerylphosphorylcholine) complex
alpha gpc powder
alphagrain
alphasize
alphasize 50% a-gpc
alphasize 50wsp
alphasize a-gpc
alphasize alpha glycerylphosphorylcholine
alphasize alpha-glyceryl phosphoryl choline
alphasize alpha-glyceryl phosphorylcholine
alphasize alpha gpc
alphasize alpha gpc 50%
alphasize gpc
alphasize l-alpha-glycerylphosphorylcholine
choline alfoscerate
choline alphoscerate
glycerophosphatidylcholine
glycerophosphocholine
glycerophosphorylcholine
glyceryl-phosphorylcholine
glycerylphosphorylcholine
glyceryophosphatidyl-choline
gpc
gpc choline
l-alpha-glycerophosphorylcholine
l alpha glycerylphosphorylcholine
l-alpha glyceryl phosphoryl choline
l-alpha glycerylphosphorylcholine
l-alpha-glyceryl phosphoryl choline
l-alpha-glycerylphosphorylcholine
l-alpha-glycerylphosphorylcholine hydrate
l-alpha glycerylphosphorylcholine powder
l-alpha gpc
l-alpha-gpc
proprietary blend (300 mg. per capsule) of:
sn-glycero (3) phosphocholine
stabilized l-alpha-glycerophosphatidylcholine
supplying alpha-glycerylphosphorylcholine
yielding 50 mg glyceryl-phosphorylcholine
Synopsis of Alpha-GPC
History
Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a natural choline compound found in the brain and in various food sources. Historically, Alpha-GPC’s medicinal use can be traced to its prominent role in European countries, particularly Italy and France, where it has been utilized since the mid-20th century as a remedy to support cognitive health and recovery from neurological conditions. Early clinical use centered around the treatment of age-related cognitive decline, stroke rehabilitation, and memory impairments, with practitioners noting improvements in mental clarity and overall brain function.
The compound’s benefits stem from its ability to increase acetylcholine levels, a neurotransmitter crucial for memory and learning. This mechanism made Alpha-GPC a valuable adjunct in traditional remedies for supporting cognitive and neurological health. Some herbal traditions have combined Alpha-GPC with natural nootropic herbs, such as Bacopa monnieri, Ginkgo biloba, and Panax ginseng, to create synergistic effects. Such combinations are designed to enhance memory, focus, and overall mental performance, leveraging both the choline-boosting properties of Alpha-GPC and the antioxidant and neuroprotective benefits of the herbs.
Alpha-GPC’s positive contributions are widely acknowledged, especially in the context of aging populations and those seeking to maintain cognitive vitality. Its use in herbal blends has further expanded its versatility, making it a popular ingredient in modern nutritional supplements. Today, Alpha-GPC continues to be regarded as a safe and effective option for supporting brain health, both as a stand-alone supplement and in combination with other botanicals for comprehensive cognitive support.
Traditional and scientific validation
Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a naturally occurring choline compound found in the brain and in various food sources. Historically, Alpha-GPC has been used in Europe as a prescription medication for treating cognitive decline, particularly in elderly populations. Its popularity has grown worldwide as a dietary supplement, often marketed to support memory, learning, and athletic performance.
Scientifically, Alpha-GPC serves as a precursor to the neurotransmitter acetylcholine, which is pivotal for memory and cognitive function. Several clinical studies have investigated its effects. Some double-blind, placebo-controlled trials have demonstrated that Alpha-GPC supplementation may benefit individuals with mild to moderate dementia, including Alzheimer’s disease, by improving cognitive scores and daily functioning. For example, research published in the journal Clinical Therapeutics and Current Alzheimer Research reported modest improvements in cognitive performance among elderly participants taking Alpha-GPC compared to placebo.
Additionally, emerging evidence suggests that Alpha-GPC may support physical performance and recovery. A few small-scale studies have indicated that it could enhance power output and growth hormone secretion in athletes, although these findings are preliminary and require further validation.
While Alpha-GPC shows promise for cognitive and physical health, the overall body of evidence remains limited, particularly regarding its long-term safety and efficacy in healthy individuals. Most experts agree that more rigorous, large-scale studies are needed to confirm its benefits and clarify its mechanisms. Nonetheless, Alpha-GPC is generally regarded as a safe supplement when used appropriately, and its role as a choline source and cognitive enhancer continues to be of significant interest in nutritional science.
Alpha-GPC is used for these health conditions
Aging (prevention) (Scientific)
Alzheimer's Disease (Scientific)
Athletic and Exercise Aids (Scientific)
Concentration (poor) (Scientific)
Confusion (Scientific)
Dementia (Scientific)
Memory and Brain Function (Scientific)
Senility (Scientific)
Thinking (cloudy) (Scientific)
Alpha-GPC is used to support these body systems
Acetylcholine (Scientific)
Brain (Scientific)
Nerves (Scientific)
Specific Neurotransmitters (Scientific)
