Agmatine
Other names for Agmatine
1-(4-aminobutyl)guanidine sulfate
agamatine sulfate
agmacore
agmamax
agmamax agmatine sulfate
agmamax(tm)
agmaphos
agmapro matrix
agmapure
agmapure agmatine sulfate
agmass
agmasure
agmatine
agmatine glycerate
agmatine sulfate
agmatine sulfate/glycerol
agmatine sulfate powder
agmatine sulphate
instantized & micronized agmatine sulfate
pure hplc agmatine sulfate
Agmatine Silicate
Agmatine sulfate
Synopsis of Agmatine
History
Agmatine, a naturally occurring derivative of the amino acid arginine, has a rich history of medicinal use, though its isolated identification and supplementation are relatively recent developments. Traditionally, agmatine's parent compound, arginine, has been consumed through various herbal and dietary sources for centuries, especially in cultures valuing natural remedies for circulatory health, wound healing, and enhanced vitality. While historical texts may not reference agmatine directly, the benefits ascribed to arginine-rich plants—such as increased energy, improved mood, and better recovery—can now be partially attributed to agmatine's unique properties.
Medicinally, agmatine has been recognized for its potential to support neurological health, cardiovascular function, and metabolic balance. In folk medicine, remedies containing seeds, roots, or extracts from arginine-rich plants were often used to alleviate pain, support digestive health, and boost mental clarity. Modern research has confirmed that agmatine, produced during fermentation and metabolic processes, acts as a neuromodulator, potentially aiding in mood regulation and pain management.
In herbal combinations, agmatine is often paired with botanicals like turmeric, ginger, and ginseng to formulate synergistic blends for improved cognitive function, enhanced workout performance, and stress resilience. These combinations harness agmatine’s ability to modulate nitric oxide synthesis and neurotransmitter activity, amplifying the positive effects of other herbal components. Overall, agmatine’s contributions to traditional and contemporary wellness strategies highlight its value as a versatile and beneficial compound, supporting both physical and mental health through a variety of mechanisms.
Traditional and scientific validation
Agmatine is a naturally occurring compound derived from the amino acid arginine and was first discovered in 1910 by Albrecht Kossel. Its presence in the human body and various foods has led to interest in its potential physiological roles and benefits. In recent years, agmatine has gained popularity as an ingredient in nutritional supplements, particularly for its purported cognitive, mood-supporting, and athletic performance-enhancing properties.
Scientific research suggests that agmatine acts as a neuromodulator and neurotransmitter, influencing several biochemical pathways. It has been studied for its potential to modulate nitric oxide synthesis, which may support vascular health and enhance blood flow—a property attractive to athletes and fitness enthusiasts. Furthermore, preclinical studies indicate possible neuroprotective and antidepressant effects, with animal models showing improvements in mood and resilience to stress. Some human studies have explored its use in managing neuropathic pain and supporting cognitive function, with preliminary results indicating potential benefits.
Despite these promising findings, comprehensive clinical validation in humans remains limited. Most of the current evidence is derived from animal models or small-scale human studies. Large, well-designed clinical trials are necessary to confirm agmatine’s efficacy and safety for various health outcomes. Nonetheless, agmatine’s multifaceted biological roles and its positive results in early research make it an intriguing compound worthy of further exploration in the field of nutritional science.
Agmatine is used for these health conditions
Addictions (drugs) (Scientific)
Alcoholism (Scientific)
Alzheimer's Disease (Scientific)
Anxiety (Scientific)
Athletic and Exercise Aids (Scientific)
Depression (Scientific)
Diabetes (Scientific)
Inflammation (Scientific)
Memory and Brain Function (Scientific)
Nerve Damage (Scientific)
Neuralgia and Neuritis (Scientific)
Pain (general remedies for) (Scientific)
Parkinson's Disease (Scientific)
Peripheral Neuropathy (Scientific)
Stress (Scientific)
Agmatine is used to support these body systems
Brain (Scientific)
Dopamine (Scientific)
Nerves (Scientific)
Specific Neurotransmitters (Scientific)
