Evidence supporting the use of: Resveratrol
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol is a polyphenolic compound primarily found in the skin of grapes, berries, and peanuts. Its use for supporting or treating wrinkles is justified by emerging scientific evidence, albeit still limited and primarily preclinical. Laboratory studies have shown that resveratrol possesses potent antioxidant properties, which can help combat oxidative stress—a key factor in skin aging and wrinkle formation. Additionally, resveratrol has been demonstrated to activate sirtuin pathways (specifically SIRT1), which are associated with cellular longevity and repair mechanisms. Some in vitro and animal studies suggest that resveratrol can enhance collagen synthesis and inhibit the activity of enzymes (like matrix metalloproteinases) that break down collagen and elastin in the skin. A handful of small clinical studies and cosmetic trials have reported improvements in skin texture, elasticity, and reduction in the appearance of fine lines after topical application of resveratrol-containing formulations. However, these studies are limited by small sample sizes, short durations, and often the use of product blends rather than pure resveratrol. There is insufficient large-scale, long-term human data to definitively confirm its efficacy against wrinkles. Nonetheless, the mechanistic plausibility and early clinical signals provide a reasonable scientific basis for its inclusion in anti-aging skincare products, but more robust research is needed for conclusive recommendations.

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