Evidence supporting the use of: L-tyrosine
For the health condition: Worry

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-tyrosine is an amino acid that serves as a precursor to several important neurotransmitters, including dopamine, norepinephrine, and epinephrine. Its use in supporting "worry"—often interpreted as chronic stress or anxiety—has some scientific basis, though the evidence is not robust enough for high confidence. Several clinical studies have investigated L-tyrosine's ability to support cognitive performance and stress resilience, primarily under conditions of acute stress (such as sleep deprivation, cold exposure, or military training). These studies suggest that L-tyrosine supplementation may help maintain cognitive function during short-term stress by ensuring sufficient neurotransmitter synthesis. However, the direct evidence for L-tyrosine as a treatment for generalized anxiety, worry, or chronic stress in otherwise healthy individuals is limited. Most studies focus on cognitive performance rather than emotional symptoms like worry or anxiety. There is some mechanistic rationale: since stress depletes catecholamine neurotransmitters, and tyrosine helps replenish them, theoretically, it could modulate mood and resilience. Despite this, controlled trials specifically targeting "worry" or anxiety as primary outcomes are scarce. In summary, L-tyrosine has some scientific backing for supporting mental performance under stress, which may indirectly help with stress-related symptoms, but direct evidence for its effectiveness specifically for "worry" is limited. More research is needed before it can be confidently recommended for this purpose.

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