Evidence supporting the use of: Adrenaline
For the health condition: Wheezing

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Adrenaline (also known as epinephrine) is scientifically validated for the treatment of wheezing, particularly in emergency settings such as severe asthma attacks and anaphylaxis. The mechanism of action involves stimulation of beta-2 adrenergic receptors in bronchial smooth muscle, leading to bronchodilation and rapid relief of airway constriction. This effect is critical in life-threatening situations where airway compromise is imminent. Clinical guidelines, including those from the World Health Organization and national asthma management protocols, endorse the use of adrenaline in severe allergic reactions (anaphylaxis) and occasionally in severe asthma unresponsive to first-line treatments. Nebulized adrenaline is also sometimes used in pediatric croup to reduce airway swelling and improve symptoms of wheezing and stridor. Multiple randomized controlled trials and meta-analyses support adrenaline’s effectiveness in these acute situations. However, for routine management of mild wheezing (e.g., mild asthma), inhaled beta-2 agonists such as salbutamol are preferred due to a better side effect profile. Adrenaline’s role in wheezing is therefore well-supported in acute, severe cases but not as a first-line treatment for chronic or mild wheezing.

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Products containing Adrenaline

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