Evidence supporting the use of: Arginine alpha-ketoisocaproate
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arginine alpha-ketoisocaproate (AAKG) has been investigated as a supplement to support or treat muscle wasting (cachexia), particularly in clinical settings such as chronic illness or critical care. The rationale for its use is based on the roles of its components: arginine, a conditionally essential amino acid involved in protein synthesis and immune function, and alpha-ketoisocaproate (KIC), a metabolite of leucine that may serve as a nitrogen scavenger and modulate amino acid metabolism. Some studies suggest that AAKG supplementation can help attenuate muscle protein breakdown and support nitrogen balance, particularly in catabolic states. A small number of clinical trials and experimental studies have evaluated AAKG or similar keto acid-amino acid combinations in patients with renal failure, cancer cachexia, or critical illness. However, these studies are limited in number, often small in scale, and sometimes use combinations of multiple amino acids or keto acids, making it difficult to isolate the effect of AAKG itself. While some results indicate possible benefit in reducing muscle wasting or improving protein balance, the overall evidence is weak and inconsistent. Major clinical guidelines do not specifically recommend AAKG for the treatment of wasting syndromes, and more robust, well-controlled trials are needed. Therefore, while there is some scientific rationale and preliminary evidence, the level of support is modest, justifying a rating of 2 out of 5.

More about Arginine alpha-ketoisocaproate
More about Wasting

Other health conditions supported by Arginine alpha-ketoisocaproate

Wasting
Wounds and Sores

Products containing Arginine alpha-ketoisocaproate

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