Evidence supporting the use of: Proanthocyanidin
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Proanthocyanidins, a class of polyphenolic compounds found in fruits, seeds, bark, and leaves (notably grape seeds and pine bark), have been scientifically investigated for their effects on the vascular system. Research suggests that proanthocyanidins exhibit potent antioxidant properties, which protect blood vessels from oxidative stress and strengthen capillary walls. Multiple clinical trials have found that proanthocyanidin-rich extracts (such as from grape seed or French maritime pine bark) can improve symptoms associated with chronic venous insufficiency (CVI), a condition where veins have trouble sending blood from the legs back to the heart. These symptoms include leg swelling, heaviness, and pain. A 2015 meta-analysis published in Phytotherapy Research concluded that grape seed proanthocyanidin extract significantly improved CVI symptoms compared to placebo. The mechanism is thought to involve enhanced venous tone, reduced capillary permeability, and inhibition of inflammatory enzymes that degrade vascular connective tissue. While the evidence is encouraging and generally supports the use of proanthocyanidins for venous health, most studies are of moderate length (several weeks to a few months) and often use standardized extracts rather than whole foods. Side effects are rare and mild. In summary, proanthocyanidins have a solid scientific basis for supporting vein health, especially in the context of chronic venous insufficiency.

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