Evidence supporting the use of: Hesperidin methylchalcone
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hesperidin methylchalcone is a flavonoid derivative commonly found in citrus fruits. It is widely used in Europe and other parts of the world to support venous health, particularly in the management of chronic venous insufficiency (CVI), hemorrhoids, and related disorders. The justification for its use is primarily scientific, as multiple clinical studies and meta-analyses have evaluated its efficacy.

Research indicates that hesperidin methylchalcone, often in combination with other flavonoids such as diosmin, can improve symptoms of venous insufficiency, including leg swelling, pain, and heaviness. Its mechanism is believed to involve strengthening capillary resistance, reducing capillary permeability, and exerting anti-inflammatory effects. A systematic review and meta-analysis published in Phytotherapy Research (2017) concluded that micronized purified flavonoid fractions (including hesperidin methylchalcone) significantly improved CVI symptoms compared to placebo.

While the evidence base is moderate, with most studies conducted in combination with other flavonoids rather than hesperidin methylchalcone alone, the consistent findings across randomized controlled trials and observational studies provide a scientific rationale for its use in supporting venous health. However, further high-quality, large-scale trials are needed to better define its independent efficacy and optimal dosing.

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Other body systems supported by Hesperidin methylchalcone

Arteries
Capillaries
Circulatory System
Veins

Products containing Hesperidin methylchalcone

We currently have no products on Caring Sunshine that contain this ingredient.