Evidence supporting the use of: Grape seed
For the body system: Veins
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Grape seed extract is used to support the veins and circulatory system, and this use is supported by moderate scientific evidence. Grape seed extract contains oligomeric proanthocyanidins (OPCs), which are recognized for their antioxidant and vascular-protective properties. Several clinical studies have investigated the effects of grape seed extract on chronic venous insufficiency (CVI), a condition characterized by poor vein function in the legs. A 2001 randomized, double-blind, placebo-controlled trial published in "Phytotherapy Research" found that grape seed proanthocyanidin extract significantly improved symptoms of CVI, such as leg heaviness and swelling, compared to placebo. Additionally, a review of randomized clinical studies in "Alternative Medicine Review" (2004) concluded that grape seed extract may help reduce edema and improve venous tone in patients with CVI.
The mechanisms proposed include enhanced capillary strength, decreased capillary permeability, and improved lymphatic drainage. While these findings are promising, the overall quality of evidence is moderate due to the limited number of large, long-term trials and variability in dosages used. Therefore, grape seed extract is considered to have a scientifically supported, but not definitively proven, role in supporting vein health, particularly in the context of mild-to-moderate venous insufficiency.
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