False Unicorn (Chamaelirium luteum) has a long history of use in traditional herbal medicine, particularly among Native American and early European settlers in North America. Traditionally, it has been used to support various aspects of female reproductive health, including the vagina, uterus, and menstrual cycle. Herbalists have used False Unicorn root to address issues such as vaginal dryness, inflammation, prolapse, and other gynecological complaints, often in combination with other herbs. The rationale for its use is based on empirical observation and anecdotal reports rather than scientific studies.

Despite its established place in traditional herbal practices, there is little to no modern scientific research that specifically validates the efficacy of False Unicorn for supporting vaginal health or treating vaginal conditions. Most contemporary herbal references cite historical uses and traditional knowledge rather than evidence from clinical trials or pharmacological studies. There is a lack of well-designed studies evaluating its safety or effectiveness for the vagina or broader reproductive system. In summary, the use of False Unicorn for vaginal health is primarily justified by tradition, with limited scientific evidence available to support its efficacy.