Evidence supporting the use of: Vitamin B9 (methyltetrahydrofolate)
For the body system: Uterus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, also known as folate or its active form, methyltetrahydrofolate, has strong scientific support for its role in supporting the uterus, particularly in the context of pregnancy and fetal development. Folate is essential for DNA synthesis, repair, and methylation, which are critical processes during cell division and growth. The uterus is a key organ in pregnancy, and adequate folate levels are crucial for healthy placental and fetal development. Clinical guidelines worldwide recommend folate supplementation before conception and during early pregnancy to prevent neural tube defects (NTDs) in the developing fetus, a benefit that directly relates to uterine and reproductive health. While the traditional focus has been on fetal outcomes, folate also contributes to the health of the endometrial lining and supports proper implantation and placental function. Methyltetrahydrofolate, the bioactive form, is particularly important for individuals with MTHFR gene mutations who cannot efficiently convert folic acid to active folate. Multiple large-scale studies and meta-analyses confirm the effectiveness of folate supplementation in reducing the risk of congenital abnormalities and supporting reproductive health, which provides a strong scientific basis for its use in supporting the uterus.

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