Evidence supporting the use of: Vitamin B9 (calcium methyltetrahydrofolate)
For the body system: Uterus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, specifically in the form of calcium methyltetrahydrofolate, is scientifically validated as an essential nutrient for uterine and reproductive health, particularly during pregnancy. Folate (Vitamin B9) plays a central role in DNA synthesis, cell division, and tissue growth—all critical processes during early embryonic and uterine development. Adequate folate intake before conception and during early pregnancy is well established to reduce the risk of neural tube defects in the developing fetus. This has led to widespread recommendations for supplementation among women of childbearing age.

Beyond its role in fetal neural tube development, folate is also involved in supporting the normal growth and maintenance of the uterine lining (endometrium), which is necessary for implantation and healthy pregnancy progression. Scientific studies have shown that deficiency in folate can lead to poor reproductive outcomes, including increased risk of miscarriage and impaired placental development. The methyltetrahydrofolate form is a bioactive version of folate that is more efficiently utilized by the body, especially in individuals with genetic variations affecting folate metabolism.

In summary, there is strong scientific evidence supporting the use of Vitamin B9 (particularly as calcium methyltetrahydrofolate) to support the uterus and reproductive system, especially for women planning pregnancy or who are pregnant. This is reflected in recommendations from public health authorities worldwide.

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