Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Thylakoids, the membrane-bound compartments found within chloroplasts of green plants, have attracted scientific interest for their potential metabolic benefits, including effects on blood lipids such as triglycerides. Several small-scale human clinical trials and animal studies have investigated the impact of thylakoid supplementation—often derived from spinach—on lipid metabolism. The underlying mechanism is thought to be related to thylakoids’ ability to delay fat digestion and absorption in the intestine, leading to increased satiety and reduced caloric intake.

In particular, research such as the randomized controlled trial by Montelius et al. (2014) in Appetite and subsequent studies suggest that thylakoid supplementation may lead to modest reductions in postprandial triglyceride levels and improvements in lipid profiles when consumed as part of a calorie-controlled diet. However, these effects have generally been modest, and the studies are limited by small sample sizes and short durations. Moreover, while some results are promising, they are not universally consistent, and larger, longer-term studies are needed to better establish efficacy.

In summary, there is early scientific evidence suggesting that thylakoid supplementation may have a beneficial effect on triglyceride levels, but the quality and quantity of evidence are not strong enough to warrant widespread clinical recommendation. The evidence rating is thus moderate but limited (2/5), and thylakoids should not be relied upon as a primary intervention for high triglycerides at this time.

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