Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Piceid is a stilbenoid glucoside found in various plants, most notably in grapes and the Japanese knotweed. It is a major resveratrol derivative. Some scientific studies have explored the effects of piceid and related compounds on lipid metabolism, including triglyceride levels. In preclinical research, particularly animal models, piceid has demonstrated the potential to reduce serum triglyceride concentrations. For instance, studies in hyperlipidemic rats and mice have shown that piceid supplementation can decrease triglyceride and cholesterol levels, likely through the modulation of lipid metabolism pathways and enhancement of antioxidant activity. In vitro studies further suggest that piceid may inhibit lipid accumulation in liver cells.

However, direct clinical evidence in humans is lacking. While these animal and cell-based studies are promising, no robust human trials have established piceid’s efficacy for lowering high triglycerides. Most of the available data are preliminary and do not yet justify widespread clinical use of piceid for this purpose. Additionally, piceid is not a well-known traditional remedy for hypertriglyceridemia. Thus, while there is a scientific rationale supported by preclinical evidence, the overall quality and quantity of evidence remain limited at this time.

In summary, piceid's use for high triglycerides is supported primarily by early-stage scientific studies, with insufficient evidence from human clinical trials to confirm its effectiveness or safety for this condition.

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