Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Testolone (RAD140) is a selective androgen receptor modulator (SARM) that has been investigated for its potential to increase muscle mass, strength, and bone density. Its primary mechanism involves selectively binding to androgen receptors in muscle and bone tissues, mimicking some of the effects of testosterone. Unlike traditional anabolic steroids, Testolone is designed to have fewer androgenic (male sex characteristic-promoting) side effects in non-target tissues such as the prostate.

Scientific studies, primarily in animal models and limited human trials, have shown that Testolone can significantly increase lean muscle mass and strength without causing substantial suppression of natural testosterone production at moderate doses. However, some degree of suppression has been noted, and there is evidence that SARMs, including Testolone, may lower endogenous testosterone levels with prolonged use or at high doses.

Testolone is not approved by the FDA for any medical indication, including the treatment of low testosterone (hypogonadism). Most current clinical and preclinical research focuses on its use for muscle wasting disorders and potentially for certain cancers. While its mechanism suggests it could theoretically support or substitute for testosterone in some respects, there is not yet robust clinical trial evidence supporting its safe and effective use in treating low testosterone in humans. As such, while the rationale for its use is grounded in science, it should not be considered a first-line or approved therapy for low testosterone.

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