Evidence supporting the use of: D-Aspartic Acid
For the body system: Testes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

D-Aspartic Acid (DAA) is an amino acid that occurs naturally in the body and is found in high concentrations in endocrine tissues, including the testes. Its use as a supplement to support testicular function, especially for boosting testosterone production, is based on some scientific evidence, primarily from animal studies and a few small human trials. DAA appears to play a role in the synthesis and release of luteinizing hormone (LH) and testosterone, both of which are crucial for testicular health and male reproductive function.

A notable human study (Topo et al., 2009) showed that healthy men taking DAA experienced a significant increase in both LH and testosterone after 12 days of supplementation. However, subsequent research has produced mixed results. Some studies in resistance-trained men found no significant effect of DAA supplementation on testosterone levels, while others observed only modest or short-term increases. Scientific consensus suggests that DAA may temporarily elevate testosterone in certain populations (e.g., infertile men or those with low baseline levels), but it appears less effective in healthy, physically active men with normal testosterone.

Overall, the scientific evidence supporting DAA for testicular support is limited and inconsistent. While there is a plausible biological mechanism and some positive findings, the magnitude and duration of effect are uncertain, and more robust, larger-scale studies are needed to clarify its true efficacy.

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