Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Whole adrenal glandular supplements have been traditionally used in naturopathic and alternative medicine to support the body's stress response and overall vitality, which are associated with the Sympathetic Nervous System (SNS). The rationale is based on the idea that consuming animal adrenal tissue may provide nutrients or "glandular factors" that support or "nourish" the corresponding human gland. Historically, such supplements were popular before the development of synthetic corticosteroids and were believed to help with symptoms of adrenal "fatigue" or exhaustion, states often attributed to prolonged stress and SNS overactivity.

However, scientific evidence for the efficacy of whole adrenal glandulars in supporting the SNS or adrenal function is extremely limited. There are no well-controlled clinical trials demonstrating that oral adrenal glandulars significantly impact human adrenal hormone levels or SNS activity. Most modern endocrinologists do not recognize "adrenal fatigue" as a medical diagnosis, and the safety and bioavailability of animal-derived adrenal extracts are not well established. While traditional use persists in some naturopathic circles, the practice is not supported by mainstream scientific research, and regulatory authorities caution about potential risks of contamination or immune reactions.

In summary, the use of whole adrenal glandulars for SNS support is primarily justified by tradition rather than scientific validation.

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