Evidence supporting the use of: Urolithin A
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Urolithin A is a metabolite produced by gut bacteria from ellagitannins, compounds found in pomegranates and some other fruits. Recent scientific research has explored Urolithin A’s effects on the structural system, particularly skeletal muscle and bone health. Preclinical studies have shown that Urolithin A can promote mitophagy (the selective degradation of damaged mitochondria), leading to improved mitochondrial function in muscle cells. Human clinical trials, though limited, indicate that supplementation with Urolithin A can improve muscle endurance and strength in older adults, which is relevant to the structural system's integrity and function.

Additionally, some animal studies suggest that Urolithin A may have a positive impact on bone health by reducing inflammation and oxidative stress, factors that contribute to bone degeneration. However, direct evidence in humans regarding bone density or fracture prevention is currently lacking. There is no significant historical or traditional use of Urolithin A for structural system support, as it is a relatively newly identified compound in scientific research.

In summary, the use of Urolithin A for supporting the structural system is grounded in emerging scientific evidence, particularly in relation to muscle health and mitochondrial function. However, larger and longer-term human studies are needed to fully validate its efficacy for broader aspects of the structural system such as bone health. The current evidence justifies a moderate rating.

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