Evidence supporting the use of: Methylsulfonylmethane (MSM)
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Methylsulfonylmethane (MSM) is a sulfur-containing compound commonly used as a dietary supplement. Its application for supporting the structural system—encompassing joints, connective tissues, cartilage, and bones—is primarily based on both preclinical rationale and clinical studies, though evidence is moderate rather than definitive. MSM is believed to support the structural system by providing sulfur, which is important for collagen and keratin synthesis, key components of connective tissue and cartilage.

Several randomized, double-blind, placebo-controlled clinical trials have investigated MSM's effectiveness, especially for joint health in osteoarthritis patients. Studies (e.g., Kim et al., Osteoarthritis Cartilage, 2006; Debbi et al., BMC Complement Altern Med, 2011) have shown that MSM supplementation can lead to reductions in pain and improvements in physical function compared to placebo. Additionally, MSM has demonstrated anti-inflammatory and antioxidant properties in laboratory and animal studies, which may contribute to its potential benefits in maintaining joint health and reducing exercise-induced muscle damage.

However, while these findings are promising, the number and size of studies are limited, and their methodological quality varies. Most research has focused on joint pain rather than broader aspects of structural support such as bone health or overall connective tissue integrity. Thus, while there is scientific support for MSM's use in supporting the structural system—particularly for joint comfort—the strength of evidence is moderate and further large-scale, high-quality studies are needed to confirm and expand upon these results.

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Other body systems supported by methylsulfonylmethane (MSM)

Hair
Immune System
Joints
Muscles
Skin
Structural System