Evidence supporting the use of: L-leucine
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

L-leucine is an essential branched-chain amino acid (BCAA) that plays a significant role in supporting the structural system, particularly skeletal muscle and connective tissue. Scientific research has validated leucine's pivotal function in stimulating muscle protein synthesis via activation of the mTOR pathway, which is crucial for muscle maintenance, repair, and growth. Several clinical studies have demonstrated that dietary supplementation with leucine or BCAA mixtures can enhance muscle protein synthesis in both healthy individuals and those experiencing muscle wasting conditions such as sarcopenia or cachexia. Additionally, leucine is critical for the preservation of lean body mass during periods of caloric restriction or aging.

While most evidence focuses on muscle tissue, leucine is also a fundamental building block for the synthesis of structural proteins found in other tissues. However, its direct effects on connective tissue (e.g., bone, cartilage) are less well established. The strongest evidence supports its role in muscle health, which is a core component of the structural system. Overall, the use of L-leucine to support the structural system is scientifically validated, especially in the context of skeletal muscle maintenance and growth.

More about L-leucine
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Other body systems supported by L-leucine

Immune System
Muscles
Structural System