Antrodia camphorata, also known as "niu-chang-chih," is a medicinal mushroom native to Taiwan. Its use for stress relief is primarily rooted in traditional Taiwanese and Chinese medicine, where it is believed to promote overall well-being and balance, sometimes specifically referenced for calming effects or as an adaptogen. In folk practice, Antrodia camphorata has been used for conditions thought to be related to stress, such as fatigue, poor sleep, and general malaise.

Scientific research on Antrodia camphorata has mostly focused on its antioxidant, anti-inflammatory, and hepatoprotective properties. There are a limited number of preclinical studies (in vitro and animal models) suggesting that extracts of Antrodia camphorata may modulate stress-related biomarkers, reduce oxidative damage, or influence the hypothalamic-pituitary-adrenal (HPA) axis. However, robust clinical trials in humans specifically investigating its efficacy for psychological stress or stress-related disorders are lacking as of mid-2024.

In summary, while Antrodia camphorata is traditionally used to support the body during stress and promote resilience, scientific validation for its use in this context remains limited, and most evidence comes from traditional practices or preliminary laboratory studies rather than well-controlled human trials.