Piper kadsura, commonly known as kadsura pepper or "haifengteng" in traditional Chinese medicine (TCM), has a documented history of use for musculoskeletal conditions such as sprains, bruises, and rheumatic pain. In TCM, Piper kadsura is considered to have properties that "dispel wind and dampness" and is used topically or internally in herbal formulations aimed at reducing swelling, alleviating pain, and promoting the healing of soft tissue injuries, including sprains. The traditional use is supported by its inclusion in classic materia medica texts and its continued presence in herbal liniments and topical preparations marketed for trauma and injury in East Asia.

However, scientific validation for these uses is limited. Some laboratory studies have identified anti-inflammatory and analgesic compounds in Piper kadsura extracts, but there are no robust clinical trials specifically evaluating its efficacy for sprains in humans. Most of the available evidence is preclinical or anecdotal, and the exact mechanisms by which it might aid tissue repair or pain relief remain speculative. In summary, while Piper kadsura’s use for sprains is well-rooted in traditional medical practice, rigorous scientific evidence is lacking, resulting in a moderate evidence rating.