Evidence supporting the use of: Tyrosine alpha ketoglutarate
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tyrosine alpha-ketoglutarate is a compound consisting of the amino acid L-tyrosine and alpha-ketoglutarate, a key intermediate in the Krebs cycle. L-tyrosine is a well-established precursor for the synthesis of catecholamine neurotransmitters, including dopamine, norepinephrine, and epinephrine. Several studies have shown that L-tyrosine supplementation can increase neurotransmitter levels under acute stress or when neurotransmitter synthesis is limited by substrate availability. This has led to its use in supporting cognitive function and mood, especially in situations of stress or fatigue. However, the majority of research focuses on L-tyrosine itself, not specifically the alpha-ketoglutarate salt. Alpha-ketoglutarate may enhance the absorption or stability of L-tyrosine, but there is little direct evidence that the combination offers substantial advantages over L-tyrosine alone for supporting neurotransmitter function. Furthermore, clinical studies directly assessing the efficacy of tyrosine alpha-ketoglutarate in the context of neurotransmitter support are lacking. The evidence base is thus limited, and its use is primarily extrapolated from the well-documented role of L-tyrosine in neurotransmitter biosynthesis. In summary, there is some scientific rationale for the use of tyrosine alpha-ketoglutarate to support neurotransmitters, primarily due to the known effects of its L-tyrosine component, but direct clinical evidence for this specific compound is limited, resulting in a moderate evidence score.

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Other body systems supported by Tyrosine alpha ketoglutarate

Brain
Dopamine
Specific Neurotransmitters

Products containing Tyrosine alpha ketoglutarate

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