Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phenylethylamine (PEA) is a naturally occurring trace amine found in the human brain and in certain foods such as chocolate. It acts as a central nervous system stimulant in humans. PEA is known to increase the release of neurotransmitters such as dopamine and norepinephrine, which are associated with mood, attention, and energy. The rationale for using PEA to support the "Specific Neurotransmitters" body system is based on its ability to enhance dopaminergic and noradrenergic neurotransmission.

Scientific validation for the use of PEA comes primarily from in vitro and animal studies, with limited small human trials. These studies suggest that oral supplementation of PEA can transiently increase synaptic concentrations of dopamine and norepinephrine, potentially improving mood and attention. However, PEA is rapidly metabolized by monoamine oxidase-B (MAO-B) in the gut and brain, limiting its bioavailability and effects when taken orally unless combined with MAO-B inhibitors. Some small clinical studies have explored its use as an adjunct in depression and attention-deficit disorders, with mixed results and generally weak evidence due to small sample sizes and methodological limitations.

Overall, while there is a scientific basis for PEA's role in neurotransmitter modulation, robust clinical evidence supporting its efficacy for specific neurotransmitter-related conditions is lacking. Therefore, its use is rated as having weak scientific validation (2/5) for supporting the neurotransmitter body system.

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