Evidence supporting the use of: Alpha-GPC
For the body system: Specific Neurotransmitters

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Alpha-GCP (Alpha-glycerylphosphorylcholine, commonly known as Alpha-GPC) is primarily used to support the Specific Neurotransmitters body system based on scientific evidence. Alpha-GPC is a natural choline compound found in the brain and is a precursor to acetylcholine, a key neurotransmitter involved in memory, learning, and other cognitive functions. Multiple clinical studies have investigated Alpha-GPC’s effects on cognitive health, particularly in elderly populations and individuals with cognitive decline.

A number of randomized controlled trials and meta-analyses have demonstrated that Alpha-GPC supplementation can improve cognitive performance, particularly memory and attention, in people with mild to moderate Alzheimer’s disease and vascular dementia. For example, a meta-analysis published in Clinical Therapeutics (2013) reviewed randomized trials and concluded that Alpha-GPC produced significant improvements in cognitive function compared to placebo and other choline precursors. The mechanism is believed to be related to increased acetylcholine synthesis and release in the brain.

While most of the evidence is in populations with cognitive impairment, there is also some research suggesting benefits for healthy individuals in supporting neurotransmitter function and cognitive resilience. Overall, Alpha-GPC is scientifically validated as a choline source that supports neurotransmitter (especially acetylcholine) activity in the brain, with a moderate to strong evidence base supporting its use for this purpose.

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Products containing Alpha-GPC

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