Evidence supporting the use of: Agnusides
For the body system: Specific Hormones
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Agnusides are iridoid glycosides found primarily in the fruit of Vitex agnus-castus, also known as chaste tree. This plant has a long history of use in traditional medicine, especially for supporting women’s hormonal health, including the management of premenstrual syndrome (PMS), menstrual irregularities, and symptoms associated with menopause. The primary hormonal system effects are thought to derive from the plant’s dopaminergic activity, which can reduce prolactin secretion via the pituitary gland, indirectly influencing the menstrual cycle and other reproductive hormones.
Modern scientific studies, including randomized controlled trials and systematic reviews, provide moderate evidence that extracts of Vitex agnus-castus can alleviate symptoms of PMS and some menstrual disorders. While most research focuses on the whole extract rather than isolated agnusides, agnusides are considered key active components. The mechanisms proposed include binding to dopamine D2 receptors, resulting in lowered prolactin levels, which can help rebalance other reproductive hormones such as estrogen and progesterone.
However, it should be noted that while there is scientific support for Vitex agnus-castus extracts in hormonal regulation, data specifically isolating agnusides’ effects are limited. Most available evidence relates to the whole extract, which contains a mixture of compounds. Nonetheless, the presence and activity of agnusides contribute to the overall effect. Therefore, the use of agnusides to support the hormonal (endocrine) system is justified by moderate scientific evidence, but more research is needed to isolate their individual effects.
Other body systems supported by Agnusides
DopamineEstrogen
Female Reproductive System
Glandular System
Hypothalamus
Ovaries
Pituitary
Pituitary (anterior)
Progesterone
Reproductive System
Specific Hormones
Uterus
