Plumbago zeylanica has a long history of use in traditional medicine systems, particularly in Ayurveda, Siddha, and folk medicine in India and other parts of Asia. One of its ethnomedicinal applications includes use as a remedy for snake bites. Healers often employed root extracts or pastes of the plant, either topically or orally, as part of complex antidote formulations. However, the basis for this use is primarily anecdotal and rooted in historical practice rather than substantiated by modern pharmacological evidence.

Scientific studies evaluating the efficacy of Plumbago zeylanica specifically against snake venom toxicity are extremely limited. While the plant contains bioactive compounds such as plumbagin, which exhibits various biological activities (e.g., antimicrobial, anti-inflammatory), robust experimental or clinical data supporting its direct anti-venom properties are lacking. A few in vitro studies have hinted that some extracts may have neutralizing effects on certain toxins, but these findings are preliminary and not widely replicated. No clinical trials or authoritative pharmacological assessments endorse its use against snake bite envenomation.

In summary, the use of Plumbago zeylanica for snake bite is primarily justified by traditional usage rather than scientific validation. The evidence rating is low due to the absence of reliable experimental or clinical data supporting effectiveness for this indication.