Evidence supporting the use of: Vitamin A
For the body system: Small Intestines

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin A plays a well-documented role in supporting the health and function of the small intestine. Scientific studies have shown that vitamin A is crucial for maintaining the integrity of the mucosal epithelium, which lines the gastrointestinal tract, including the small intestine. This vitamin supports the differentiation and function of epithelial cells, helping to create a barrier against pathogens and facilitating nutrient absorption. Vitamin A deficiency is associated with impaired mucosal immunity, increased susceptibility to infections, and disruptions in gut barrier function. Several animal and human studies have demonstrated that vitamin A supplementation improves intestinal mucosal integrity and immune response, especially in malnourished populations or individuals with gastrointestinal diseases. Furthermore, vitamin A and its metabolites (such as retinoic acid) are involved in regulating immune cells within the gut-associated lymphoid tissue (GALT), which is essential for local immune surveillance and response. Thus, the use of vitamin A to support the small intestine is justified by a robust body of scientific evidence, particularly related to gut barrier maintenance and immune defense. However, supplementation should be approached with caution since excessive vitamin A can be toxic.

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