Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Phospholipids are a class of lipids that are a major component of all cell membranes, including those lining the small intestine. Their amphipathic nature (having both hydrophilic and hydrophobic parts) allows them to form the lipid bilayer structure essential for cellular integrity and function. Scientific research supports the importance of phospholipids in the digestive tract, particularly in the small intestine, where they play roles in maintaining mucosal barrier function, aiding nutrient absorption, and modulating inflammatory responses. For example, studies have shown that dietary phospholipids, such as phosphatidylcholine, can help protect the intestinal mucosa from damage, reduce intestinal permeability ("leaky gut"), and support overall gut barrier function (Stremmel et al., 2014). Additionally, phospholipids are involved in the emulsification of dietary fats, facilitating their absorption by forming micelles in conjunction with bile salts. Some clinical and preclinical studies suggest that supplementation with specific phospholipids may benefit individuals with certain gastrointestinal conditions, such as ulcerative colitis. However, while there is a mechanistic and some clinical basis for their support of small intestine health, more large-scale, high-quality human trials are needed for conclusive evidence. Thus, the use of phospholipids for supporting small intestine function is scientifically plausible and supported by moderate evidence.

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