Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-glutamine is an amino acid that is often used to support the health of the small intestine, particularly in the context of "leaky gut" or increased intestinal permeability. Scientific evidence supports its role in intestinal health, though most studies are preclinical or involve specific clinical scenarios, such as patients with short bowel syndrome, critical illness, or following chemotherapy. Research indicates that glutamine serves as a key fuel source for enterocytes (the cells lining the small intestine) and may help maintain the integrity of the intestinal mucosa. Some clinical trials have shown that glutamine supplementation can reduce intestinal permeability and improve gut barrier function under stress or injury. However, evidence for its use in otherwise healthy individuals, or for general gut health, is limited. A 2017 review in Nutrients concluded that glutamine can be beneficial for gut barrier function, particularly in states of stress or injury, but called for more robust human trials. Overall, while the biological rationale is strong and there is supportive evidence in specific medical contexts, the evidence for routine use in the general population is moderate, not definitive.

More about L-glutamine
More about Small Intestines

Other ingredients that support Small Intestines

Other body systems supported by L-glutamine

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