Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Allyl isothiocyanate (AITC), a compound found in mustard, horseradish, and wasabi, has a long history of traditional use for treating minor skin infections and irritations. In folk medicine, mustard plasters and poultices—containing ground mustard seeds rich in AITC—were applied topically to the skin for their perceived warming, counterirritant, and antimicrobial properties. The rationale for these applications stems from AITC’s pungent nature and its ability to induce local hyperemia (increased blood flow), which was believed to help “draw out” infections or toxins.

Scientific studies have demonstrated that AITC possesses antimicrobial activity against several bacteria and fungi in vitro, including pathogens commonly implicated in skin infections (e.g., Staphylococcus aureus). However, robust clinical evidence supporting its efficacy and safety for treating skin infections in humans is lacking. Reports of skin irritation and blistering have also been documented with topical use, limiting its practical application.

In summary, while the traditional use of AITC-containing preparations for skin infections is well documented, scientific validation is limited to laboratory studies. Its use persists mainly due to historical precedent rather than strong clinical evidence.

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