Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Allantoin is a well-established ingredient in dermatology and cosmetic formulations for its skin-soothing and moisturizing properties, especially in the management of dry and flaky skin. Scientifically, allantoin is recognized as a keratolytic agent, meaning it promotes the shedding of dead skin cells and enhances the process of skin cell turnover. This action helps to smooth rough skin and reduce flakiness. Additionally, allantoin has demonstrated mild anti-inflammatory effects, which can further benefit compromised, dry skin by reducing irritation.

Multiple in vitro and in vivo studies have shown that allantoin can increase water content in the stratum corneum (the outermost layer of skin), leading to improved skin hydration and a softer texture. Its use is also supported by clinical experience, especially in over-the-counter creams, ointments, and lotions targeting xerosis (abnormally dry skin). The U.S. Food and Drug Administration (FDA) recognizes allantoin as a safe and effective skin protectant for use in non-prescription skin care products. However, while the evidence base is solid for topical use in dry and flaky skin, the number of large, high-quality clinical trials is limited, and most evidence comes from smaller studies, laboratory research, and extensive clinical usage.

Overall, allantoin’s efficacy in treating dry and flaky skin is supported by scientific rationale, documented mechanism of action, and regulatory approval, warranting a moderate evidence score.

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More about Skin (dry and/or flaky)

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