Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin K, specifically the menaquinone form (Vitamin K2), has scientific validation for its role in supporting skeletal health. Several studies have shown that Vitamin K2 is important for the carboxylation of osteocalcin, a protein essential for binding calcium to the bone matrix. This process helps in maintaining bone mineral density and reducing the risk of fractures. Clinical trials and meta-analyses suggest that Vitamin K2 supplementation can improve bone strength and reduce bone loss, particularly in postmenopausal women who are at higher risk for osteoporosis. For example, randomized controlled trials in Japan have demonstrated that menaquinone-4 supplementation reduces vertebral fractures in osteoporotic women. Additionally, observational studies have found correlations between higher dietary Vitamin K intake and greater bone density.

While Vitamin K1 (phylloquinone) is primarily involved in blood clotting, Vitamin K2 (menaquinone) is more directly linked to bone health. The mechanism involves activation of bone-building proteins and regulation of calcium deposition, preventing calcification in blood vessels and directing calcium to bones. Based on current evidence, leading health authorities, including the European Food Safety Authority (EFSA), recognize the contribution of Vitamin K to the maintenance of normal bones. However, it should be noted that while the evidence is strong, it is not universally conclusive for all populations and further large-scale studies are ongoing. Nevertheless, the scientific basis for Vitamin K2 in bone support is considered substantial.

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