Evidence supporting the use of: Transforming growth factor
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Transforming Growth Factor (TGF), particularly TGF-beta, is scientifically validated as a key regulator in bone biology. TGF-beta is a multifunctional cytokine that plays a critical role in skeletal development, bone remodeling, and repair. It is abundant in the bone matrix and released during bone resorption, where it acts on osteoblasts (cells responsible for bone formation) to stimulate the synthesis of bone matrix proteins and promote bone formation. Scientific research has shown that TGF-beta modulates both osteoblast and osteoclast activity, thereby balancing bone deposition and resorption. Studies in animal models and in vitro experiments consistently demonstrate that TGF-beta signaling is essential for normal bone growth, fracture healing, and maintenance of bone mass. Dysregulation of TGF-beta pathways has also been implicated in bone diseases such as osteoporosis and osteogenesis imperfecta. While TGF-beta's therapeutic application in humans is still under investigation and not yet widely used clinically due to potential side effects and complexities of delivery, the foundational science supporting its role in skeletal health is strong. Therefore, its use to support the skeletal system is justified by robust scientific evidence, albeit mostly at the experimental or preclinical level.

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