Polygonatum, commonly known as Solomon's Seal, has a long history of use in Traditional Chinese Medicine (TCM) and other herbal traditions. In TCM, Polygonatum species such as Polygonatum sibiricum (Huang Jing) are believed to nourish the kidneys, which are traditionally associated with bone health and longevity. TCM theory holds that the kidneys "govern the bones," and thus herbs that tonify kidney energy are thought to support skeletal health. Historical texts and herbal formularies often include Polygonatum as an ingredient in remedies intended to strengthen bones, treat joint pain, and alleviate symptoms related to bone weakness or degeneration.

However, while there are preclinical studies suggesting Polygonatum extracts may have antioxidant, anti-inflammatory, and even osteogenic (bone-forming) properties, rigorous clinical evidence in humans for direct bone health benefits is lacking. Most of the available research is limited to animal models or in vitro experiments. These studies show promising effects on bone metabolism and potential for stimulating osteoblast (bone-forming cell) activity, but the translation of these findings to human health outcomes remains unproven. As such, the use of Polygonatum for skeletal support is primarily justified by traditional use rather than robust scientific validation.