Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones are a class of phytoestrogens—plant-derived compounds with estrogen-like activity—found predominantly in soybeans and other legumes. Their use in supporting the skeletal system, particularly bone health, is supported by a moderate body of scientific evidence. Isoflavones are thought to exert beneficial effects on bone metabolism largely due to their ability to bind to estrogen receptors, mimicking some of the protective effects of endogenous estrogen on bone. This has particular relevance for postmenopausal women, who are at increased risk for osteoporosis due to declining estrogen levels.

Clinical studies and meta-analyses have shown that supplementation with soy isoflavones may help reduce bone loss and improve bone mineral density (BMD) in postmenopausal women. For example, a 2017 meta-analysis in Osteoporosis International concluded that soy isoflavones had a modest but statistically significant effect in slowing bone loss at the lumbar spine and femoral neck. However, the effect size is generally smaller than that seen with standard osteoporosis medications, and not all studies have shown consistent benefits.

The scientific consensus is that isoflavones may play a supportive role in bone health, especially where estrogen levels are low, but further research is needed to clarify their efficacy and determine optimal dosing. Their use is justified by scientific evidence, but the strength of evidence is moderate, not unequivocal.

More about Isoflavones (mixed)
More about Skeletal System (Bones)

Other ingredients that support Skeletal System (Bones)

Other body systems supported by Isoflavones (mixed)

Products containing Isoflavones (mixed)