Evidence supporting the use of: Insulin-like growth factor
For the body system: Skeletal System (Bones)

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Insulin-like growth factor (IGF), particularly IGF-1, has a well-documented role in bone metabolism and skeletal development. IGF-1 is a hormone structurally similar to insulin and is primarily produced in the liver in response to growth hormone stimulation. Scientific studies have shown that IGF-1 promotes the proliferation and differentiation of osteoblasts, the cells responsible for bone formation. It also enhances the synthesis of bone matrix proteins and stimulates the activity of chondrocytes in the growth plate, which is essential for longitudinal bone growth during childhood and adolescence.

Clinical and animal studies have demonstrated that IGF-1 deficiency leads to impaired bone growth and reduced bone density, while higher IGF-1 levels are associated with increased bone mass and improved bone healing. Furthermore, IGF-1 is implicated in the maintenance of bone turnover and repair in adults, contributing to bone remodeling and strength. Some therapies targeting the GH/IGF-1 axis are under investigation for osteoporosis and other bone-related disorders. However, while the biological rationale and some clinical evidence exist, IGF-1 itself is not commonly used as a direct supplement for bone health outside of experimental or specific medical contexts, and its therapeutic use is limited due to potential side effects and regulatory issues. Thus, the evidence is moderate but clear for IGF-1’s role in supporting the skeletal system.

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