Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Calcium hydroxyisocaproate (also known as CaHMB or the calcium salt of β-hydroxy β-methylbutyrate, HMB) is a metabolite of the amino acid leucine. There is moderate scientific evidence supporting its use for skeletal system (bone) health. Research has shown that HMB supplementation may have beneficial effects on bone metabolism, particularly in populations at risk for bone loss, such as older adults and postmenopausal women. Animal studies and some clinical trials suggest that HMB can reduce bone resorption and increase bone mineral density, possibly by promoting calcium retention and influencing osteoblast and osteoclast activity.

One clinical study found that HMB supplementation, combined with vitamin D and exercise, improved bone mass in older adults. The mechanism is thought to involve both anti-catabolic (reducing breakdown) and anabolic (building) effects on bone tissue. However, while there is promising data, the total number of high-quality human trials is still limited, and most studies have used HMB rather than specifically the calcium salt form (CaHMB), though both are used interchangeably in supplements.

In summary, calcium hydroxyisocaproate has some scientific validation for supporting bone health, but more robust, large-scale human studies are needed to confirm these effects and clarify optimal dosing and populations who may benefit most.

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