Moroccan oregano (Origanum compactum) is traditionally used in Moroccan and Mediterranean herbal medicine, including as a remedy to support respiratory health and the sinuses. Folk uses include infusions and essential oil inhalations for relief from congestion, coughs, and sinus discomfort. The primary active compounds in oregano—such as carvacrol and thymol—are known for their antimicrobial and anti-inflammatory properties, which may theoretically benefit respiratory and sinus health. However, most of the scientific research on oregano pertains to related species, such as Origanum vulgare, and focuses on general antimicrobial effects rather than specific sinus support. There is limited direct clinical evidence supporting the use of Moroccan oregano for sinus health. The justification for its use in supporting the sinuses, therefore, is primarily rooted in traditional herbal practices rather than robust scientific validation. While laboratory studies suggest oregano essential oil has potential to inhibit certain pathogens, translating this to effective sinus support in humans remains unproven. In summary, Moroccan oregano’s use for sinus support is based on traditional herbal applications, with only modest supporting evidence from laboratory studies and a lack of high-quality clinical trials.