Evidence supporting the use of: Vitamin B6 (pyridoxine)
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) plays a crucial role in the synthesis of neurotransmitters, including serotonin, by serving as a coenzyme in the conversion of the amino acid tryptophan into serotonin. Scientific studies have demonstrated that vitamin B6 is necessary for the activity of aromatic L-amino acid decarboxylase, an enzyme that catalyzes the final step in serotonin biosynthesis. Deficiency in vitamin B6 can lead to lowered serotonin and other neurotransmitter levels, which may manifest as mood disturbances or depressive symptoms. Some clinical research suggests that supplementation with vitamin B6 may improve mood or reduce symptoms of depression, particularly in individuals with low baseline B6 status. However, evidence for its efficacy as an adjunctive treatment for depression or anxiety is mixed, and large-scale, high-quality randomized controlled trials are limited.

Overall, the link between vitamin B6 and serotonin synthesis is well-established biochemically. Its use to support the serotonin system is scientifically justified on the basis of its required role in neurotransmitter production. However, the clinical benefits of supplementation, especially in individuals without deficiency, are less certain. Thus, the evidence rating is moderate (3 out of 5) due to the strong mechanistic rationale but only modest clinical evidence.

More about Vitamin B6 (pyridoxine)
More about Serotonin

Other body systems supported by Vitamin B6 (pyridoxine)

Blood
Brain
Glandular System
Immune System
Nerves
Serotonin

Products containing Vitamin B6 (pyridoxine)

We currently have no products on Caring Sunshine that contain this ingredient.