Evidence supporting the use of: Valerenic acid derivatives
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Valerenic acid is a bioactive constituent found in the roots of Valeriana officinalis (valerian), a plant traditionally used for its sedative and anxiolytic effects. Scientific interest has focused on its mechanism of action in the central nervous system, particularly its potential modulation of the serotonin (5-HT) system. Preclinical studies suggest that valerenic acid may interact with serotonin receptors, specifically 5-HT5A and 5-HT1A subtypes, and inhibit serotonin reuptake, which could theoretically enhance serotonergic neurotransmission. This is relevant because the serotonin system plays a crucial role in mood regulation, anxiety, and sleep. However, direct clinical evidence in humans demonstrating that valerenic acid or its derivatives specifically support or modulate the serotonin system is limited. Most human studies on valerian focus on sleep and anxiety, and the role of valerenic acid in these effects is presumed rather than clearly demonstrated. The majority of evidence comes from animal models or in vitro research, with only indirect support for a serotonergic mechanism. Thus, while there is a scientific rationale for valerenic acid's influence on the serotonin system, the current evidence in humans is preliminary and not robust. More research is needed to fully elucidate its effects and therapeutic potential for serotonin-related disorders.

More about Valerenic acid derivatives
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Other body systems supported by Valerenic acid derivatives

Brain
GABA
Nerves
Serotonin

Products containing Valerenic acid derivatives

We currently have no products on Caring Sunshine that contain this ingredient.