Evidence supporting the use of: Safranal
For the body system: Serotonin

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Safranal is a major volatile compound derived from the stigmas of Crocus sativus L. (saffron). Its use to support the serotonin system is justified by scientific evidence, primarily from preclinical and a limited number of clinical investigations. Safranal has been shown in animal studies to exert antidepressant-like effects, which are thought to be mediated through modulation of the serotonergic system. Research suggests that safranal may inhibit serotonin reuptake, thereby increasing serotonin availability in the synaptic cleft—a mechanism shared by certain conventional antidepressants. For example, a study published in "Phytotherapy Research" (2010) demonstrated that safranal administration resulted in increased serotonin levels and reduced depressive behaviors in mice.

Clinical studies on saffron extracts (which contain safranal along with crocin and other constituents) have demonstrated positive effects on mood and symptoms of depression in humans. However, the specific contribution of safranal, isolated from other saffron compounds, is less well studied in human trials. Most human data pertain to whole saffron or standardized extracts rather than safranal alone. Nevertheless, the preclinical evidence, along with saffron’s observed effects in humans, supports the plausibility of safranal influencing the serotonin system.

In summary, there is scientific—though not definitive—evidence that safranal may support the serotonin system, mainly based on animal models and mechanistic research, with some indirect support from clinical studies of saffron extracts.

More about Safranal
More about Serotonin

Other body systems supported by Safranal

Brain
Digestive System
Eyes
GABA
Serotonin

Products containing Safranal

We currently have no products on Caring Sunshine that contain this ingredient.