Evidence supporting the use of: Passionflower
For the body system: Serotonin

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Passionflower (Passiflora incarnata) has a long history of traditional use primarily for its calming and anxiolytic properties, rather than direct support of the serotonin system. In traditional herbal medicine, especially in Native American and European contexts, passionflower has been used to alleviate symptoms of anxiety, insomnia, and nervousness. Its sedative effects are thought to arise from compounds such as flavonoids and alkaloids that interact with the central nervous system, though the exact mechanisms remain unclear. While some preclinical studies suggest that passionflower may influence neurotransmitters, including possible weak modulation of the serotonin system, there is no strong evidence that it directly or significantly supports serotonin levels or function in humans. Most clinical research focuses on its ability to help with anxiety and sleep, not specifically serotonin modulation. Therefore, while passionflower is traditionally used for related nervous system support, its application for the "Serotonin body system" is not well established or scientifically validated at this time.

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