Evidence supporting the use of: L-proline
For the health condition: Scars / Scar Tissue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-proline is an amino acid that plays a critical role in the synthesis of collagen, the main structural protein in skin and connective tissues. Collagen is essential for wound healing and tissue repair, processes that are directly relevant to the formation and remodeling of scar tissue. Scientific studies have shown that proline is one of the most abundant amino acids in collagen, and its availability can influence collagen production and quality. Animal and cell studies suggest that supplementing with proline, or ensuring adequate intake through diet, may support collagen synthesis and potentially improve wound healing outcomes. However, there is limited direct clinical evidence in humans specifically demonstrating that L-proline supplementation alone significantly improves scar healing or reduces scar tissue formation compared to standard care or other amino acids. Most of the clinical research on scar treatment focuses on broader nutritional support, topical treatments, or surgical interventions rather than isolated L-proline supplementation. Therefore, while the biological rationale for proline’s role in scar tissue repair is strong and scientifically plausible, high-quality human studies directly validating its therapeutic use for scars are lacking. For this reason, the evidence is rated 2 out of 5—there is a scientific basis and some supporting evidence, but robust clinical validation is limited.

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