Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Folinic acid, a form of vitamin B9 distinct from folic acid, is scientifically validated in its role supporting the reproductive system, particularly in the context of fertility and pregnancy. Adequate folate levels are crucial for DNA synthesis, repair, and methylation—processes vital for the development of the embryo and the health of reproductive cells. Folinic acid, as a metabolically active form, bypasses certain metabolic defects that impair folic acid utilization, such as MTHFR mutations, which are relatively common in the population. Clinical guidelines recommend folate supplementation before and during pregnancy to reduce the risk of neural tube defects and other congenital anomalies. Several studies have also suggested folate’s role in improving oocyte quality, supporting sperm health, and reducing risks of miscarriage and preterm birth. Folinic acid is sometimes used in women with known folate metabolism issues or those who do not adequately respond to standard folic acid supplementation. While most scientific focus is on folic acid, folinic acid is recognized as an effective alternative in select clinical scenarios, with support from both clinical research and expert consensus. However, for the general population without specific metabolic concerns, folic acid remains the standard recommendation. Overall, the evidence for folinic acid’s use in reproductive health is strong, especially in subpopulations with folate metabolism challenges.

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